APSD Services Using The A3G

A3G has demonstrated that it can produce very high precision data very fast. This data has been published at the RDD (Respiratory Drug Delivery) meeting in Nice, France. For those customers who do not wish to make capital investments and yet need to get high precision data quickly, there is an alternative—outsource it to Lab Automate—we become your analytical laboratory. Existing ACI methods are quite easily ported to the A3G, as internally it uses the ACI without modifying it. We work closely with customers to port the methods. If at some point of time customers require to bring the system in-house, we will sell the system to them, so that their needs continue to be met uninterrupted.

HIGH PRECISION DATA

Recovery of Beclomethasone Dipropionate (n=3)

Sample	Area (mV.s)
Sample	Trial 1	Trial 2	Trial 3	Mean	%RSD
Mouth Piece + Induction Port + Entrance Cone	633916	667525	694897	665446	4.59
IP 1+S0	106631	92958	100562	100050	6.85
IP 2+S1	21901	23074	24430	23135	5.47
IP 3+S2	26202	25218	24759	25393	2.90
IP 4+S3	128433	125085	125093	126203	1.53
IP 5+S4	473662	455849	465866	465125	1.92
IP 6+S5	695762	681555	693435	690250	1.10
IP 7+S6	310304	306707	309955	308988	0.64
IP 8 +S7	151644	156621	155060	154441	1.65

IP =Impaction Plate. IP1 is below Stage 0, IP2 is below Stage 1, and in this manner, finally, IP8 is below Stage 7

Recovery of Fluticasone Propionate using GSK Flovent. The sample prep was done using the A3G and the Chromatography was done by ZYDUS PHARMACEUTICALS.

(GSK Flovent pMDI) Fluticasone Propionate ACI
		RUN 1	RUN 2	RUN 3	RUN 4	RUN 5	RUN 6	RUN 7	RUN 8
Sr. No.	Sample name	% LC-220 mcg	% LC-220 mcg	% LC-220 mcg	% LC-220 mcg	% LC-220 mcg	% LC-220 mcg	% LC-220 mcg	% LC-220 mcg	%RSD
1	Mouthpiece Adaptor	5.81	5.68	5.29	5.69	5.69	5.85	5.45	5.64	3.27
2	Induction Port	48.24	45.32	45.87	45.56	47.96	44.13	41.74	43.02	4.97
3	Cone	0.12	0.13	0.13	0.12	0.14	0.1	0.1	0.12	11.79
4	Impaction Plate-1 + Stage 0	3.03	2.83	2.88	2.76	2.9	3.06	2.69	3.45	8.04
5	Impaction Plate-2 + Stage 1	1.86	3.3	3.39	3.44	3.7	3.45	3.52	3.75	18.23
6	Impaction Plate-3 + Stage 2	5.05	5.11	5.31	5.55	5.92	5.63	5.62	5.82	5.76
7	Impaction Plate-4 + Stage 3	14.3	14.84	15.32	16.25	16.22	15.27	15.41	15.92	4.38
8	Impaction Plate-5 + Stage 4	15.05	14.95	15.5	16.32	15.86	15.39	15.49	15.78	2.86
9	Impaction Plate-6 + Stage 5	5.53	5.29	5.4	5.75	5.71	5.5	5.57	5.5	2.72
10	Impaction Plate-7 + Stage 6	0.7	0.67	0.68	0.72	0.72	0.72	0.68	0.72	3.09
11	Impaction Plate-F + Stage 7	0.2	0.28	0.2	0.25	0.28	0.27	0.24	0.24	13.09
12	Stage-F	0.17	0.22	0.24	0.25	0.22	0.2	0.19	0.21	12.26
Mass Balance		100.06	98.62	100.21	102.66	105.32	99.57	96.7	100.17	2.58